MRE11
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Diagn Pathol. 2019 Jun 21;14(1):60.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ea.jpg?v=1669029816)
![Figure 2:Western blot analysis using MRE11 mouse mAb against Hela (1), A431 (2), MCF-7 (3), Jurkat (4), HepG2 (5), K562 (6), COS-7 (7), PC-12 (8) and NIH/3T3 (9) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433lwb.jpg?v=1669029816)
![Figure 3:Flow cytometric analysis of Hela cells using MRE11 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433fcm-1.jpg?v=1669029816)
![Figure 4:Flow cytometric analysis of K562 cells using MRE11 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433fcm-2.jpg?v=1669029816)
![Figure 5:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using MRE11 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ihc-1.jpg?v=1669029816)
![Figure 6:Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using MRE11 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ihc-2.jpg?v=1669029816)
![Figure 7:Immunohistochemical analysis of paraffin-embedded Mouse testis tissues using MRE11 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ihc-3.jpg?v=1669029816)
![Figure 8:Immunohistochemical analysis of paraffin-embedded Rat testis tissues using MRE11 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ihc-4.jpg?v=1669029816)
![Figure 9:Immunohistochemical analysis of paraffin-embedded Rabbit testis tissues using MRE11 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32433ihc-5.jpg?v=1669029816)