CAR-T Cell Design
Accelerate your research by partnering with the field's most experienced CAR-T cell development CRO & CDMO. As the first CRO to offer CAR-T services, we have more years of experience than any other service provider and use our expertise to provide complete solutions for your project.
- Custom CRO & CDMO services with speedy response times
- End-to-end solution without the need to manage multiple vendors
- Experienced scientists maximize your efficiency
- 10+ years of experience generating CAR-T cells increase your success rates
Choose ProMab For End-to-End Cancer Research & Clinical Development Solutions
We understand that innovative solutions need scientists with the freedom to change the future. To help you harness the power of CAR-Ts in the fight against disease, we offer a complete solution from CAR-T cell design and discovery research to clinical development.
Driving Your Discovery Research Programs
Our CAR-T Platform has 10 core components that are fully customizable and offered in any configuration. A typical service starts with CAR-T cell design, then moves on to selecting the best options for CAR gene delivery, including lentivirus production, mRNA electroporation, and lipid nanoparticle transfection. Finally, through expansion and validation of the finished product, we exercise a full toolbox of functional assays to ensure we meet your performance targets. We continuously iterate at the CAR-T cell engineering stage as needed to achieve your project goals.
However, if you need CAR-T cell production without custom services, we can manufacture CAR-T cells at scales of 1 x 10^9 cells or more with our large-scale WAVE and G-Rex bioreactors. We follow up T cell expansion with CAR expression validation and functionality testing.
By choosing ProMab for your CAR-T project, you can take advantage of our proprietary and patented innovations—and deep scientific expertise—which include:
⦁ Bispecific scFv engineering
⦁ Novel costimulatory domains
⦁ iCas9 suicide switches
⦁ New detection tags
Partner with us to benefit from expert advice that will expand the possibilities for your out-of-the-box thinking.
Advancing Your Preclinical and Clinical Development
Our CAR-T offering also includes the ability to conduct preclinical and clinical development studies supported by our in-house vivarium and 2 GMP manufacturing facilities. With 100+ CAR-T in vivo models built—20+ out-licensed—and 3+ Phase 2 clinical trials initiated, we have the experience to successfully complete your CAR-T discovery and development project needs.
We offer several methods for engaging with our development capabilities, including licensing and partnering—contact us to learn more.
Discovery Services Timelines
Monoclonal Antibody Development
Choose from any of our mouse, rabbit, and human antibody development platforms for the validated design and development of your monoclonal antibodies.
Vector Packaging
Expand the possibilities of your T-cell engineering with the ability to package novel co-expression constructs and any generation of CAR domain into your viral vector.
Activation and Expansion
Fuel your animal studies with CAR T-cell production up to a large scale and get T-cell activation, lentiviral transduction, and CAR-T expansion that power your validation studies.
QC measurements
Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with over 3,000 CAR-T constructs under our belt.
Discovery Services Plans
We offer the following plans for standard projects but can customize a service to meet any project’s needs.
PLAN A
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase I (optional) | Immunization of Balb/C mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly-presented antigen. | $6,995 |
| Phase II (optional) | Sequencing of the antibody's heavy and light chains. | $1,800 |
| Phase III | Synthesis and cloning of a scFv with selected CAR domains into a lentivirus vector. Generation of 1x10^8 lentivirus viral particles. | $7,000 |
| Phase IV | T cell activation, lentiviral transduction, and CAR-T expansion. Measurement of CAR expression. | $6,000 |
| Phase V | Cytotoxicity assay, followed by INF-γ & IL-2 measurement by ELISA. | $7,000 |
PLAN B
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase III | Synthesis and cloning of a scFv with selected CAR domains into a lentivirus vector. Generation of 1x10^8 lentivirus viral particles. | $7,000 |
| Phase IV | T cell activation, lentiviral transduction, and CAR-T expansion. Measurement of CAR Expression. | $6,000 |
| Phase V | Cytotoxicity assay, followed by INF-γ & IL-2 measurement by ELISA. | $7,000 |
| Phase VI | NSG/NOG xenograft model | Starting at $15,000 |
21+
years in antibody engineering
100+
CAR-T cell design projects completed in vivo
500+
in vitro projects in CAR-T cell engineering
3K+
CAR-T and CAR-NK cells generated
Featured Publications
FAQs
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