Custom CAR-Macrophage Cell Development
As the most experienced CRO in the CAR-T cell industry, having developed over 60 types of CAR-T/NK cells and target cells, we have applied our extensive knowledge of CAR-technology to developing CAR-macrophages. Partnering with our custom service allows you to design CAR-macrophages for your research, leveraging our knowledge and platform to accelerate your cancer innovations.
- Use CAR-macrophages to explore targeted phagocytosis in your research.
- Generate the CAR construct using our existing library.
- Experiment with activating helper T-cells with CAR-macrophages.
- Study CAR-macrophages within the tumor microenvironment.
Explore new frontiers in cancer research
Engineering macrophages with CAR allows them to recognize cancer cells more effectively, target specific antigens, trigger phagocytosis, and directly present antigens to helper T-cells. This makes CAR-macrophages an exciting new tool for cancer research, enabling you to develop novel tumor microenvironment research. Our custom development package builds on our extensive knowledge platform and provides you with the resources you need to explore the new frontiers of cancer immunotherapy.
Streamlining Your Preclinical and Clinical Development
By leveraging our extensive CAR construct experience, we were able to develop preclinical and clinical services as part of our CAR-macrophage offering. With our in-house vivarium and 2 GMP manufacturing facilities, we are fully equipped to take care of your CAR-macrophage project needs.
We offer a range of methods for engaging with our development capabilities, including options for licensing and partnering. Contact us to find out how we can streamline your preclinical and clinical development today.
Discovery Services Timelines
Leverage our in vitro and in vivo services to meet all of your discovery needs within one organization, making the process fast and simple for you. Whatever your starting point, you can tailor our discovery services to suit your project and accelerate your research timeline.
Develop Antibodies
Create mouse, rabbit, and human monoclonal antibodies using our validated antibody design and development platforms.
Package Vectors
Innovate your cancer immunotherapies by packaging novel co-expression constructs and any generation of CAR domain into your vectors.
Scale Production
Expand your research horizons with scalable CAR-macrophage cell production from our GMP manufacturing facilities.
Ensure Quality
Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with years of CAR immune cell experience.
Service plans and prices
ProMab can help you advance your ideas and technologies with two different plans:
Plan A
Generate the entire construct from a mouse monoclonal antibody or fully human single-chain variable antibody fragment (scFv) from our existing library.
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase I | Immunization of BALB/c mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly presented antigen. | $6,995 |
| Phase II | Sequencing of the antibody's heavy and light chains. | $1,800 |
| Phase III | Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Mid-scale generation of high titer (>1x10^8) lentivirus viral particles. | $8,500 |
| Phase IV | Macrophage-cell isolation, lentiviral transduction, CAR-macrophage culture, and CAR validation by FACS. | $7,500 |
| Phase IV-A | Phagocytosis Assay by flow cytometry to determine the percentage of CAR-macrophage cells | $2,000 |
| Phase IV-B | Phagocytosis Assay by phase contrast microscopy to determine the percentage of CAR-macrophage cells | $2,000 |
| Phase V | Cytokine release assay to measure IL-6, IL-10, and GM-CSF release during target cell engagement. | $4,000 |
Plan B
Construct a CAR based on your antibody sequence.
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase III |
Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Mid-scale generation of high titer (>1x10^8) lentivirus viral particles. |
$8,500 |
| Phase IV | Macrophage-cell isolation, lentiviral transduction, CAR-macrophage culture, and CAR validation by FACS. | $7,500 |
| Phase IV-A | Phagocytosis Assay by flow cytometry to determine percentage of CAR-macrophage cells | $2,000 |
| Phase IV-B | Phagocytosis Assay by phase contrast microscopy to determine percentage of CAR-macrophage cells | $2,000 |
| Phase V | Cytokine release assay to measure IL-6, IL-10, and GM-CSF release during target cell engagement. | $4,000 |
Explore CAR-macrophages today
We’ll take care of your CAR-macrophage development so that you can focus on insights and innovations. Together, we can change the way the world treats cancer.
5,000+
monoclonal antibodies generated
50+
filed patents
500+
CAR-T project finished
4
Phase 2 clinical trials started
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FAQs
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