LRP6 Primary Antibody

Item Information

Catalog #

Size

Price

Description

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Product Overview

Entrez GenelD

4040

Aliases

ADCAD2; STHAG7

Clone#

1A3F5

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of human LRP6 (AA: extra 1198-1370) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

FCM (Flow Cytometry)

1/200 - 1/400

ELISA

1/10000

References

1.Cancer Biomark. 2017;19(2):151-159.
2.Int J Med Sci. 2014 May 2;11(7):685-90.

Product Image

Elisa

Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western Blot

Figure 2:Western blot analysis using LRP6 mAb against human LRP6 (AA: extra 1198-1370) recombinant protein. (Expected MW is 45 kDa)

Figure 2:Western blot analysis using LRP6 mAb against human LRP6 (AA: extra 1198-1370) recombinant protein. (Expected MW is 45 kDa)

Western Blot

Figure 3:Western blot analysis using LRP6 mAb against HEK293 (1) and LRP6 (AA: extra 1198-1370)-hIgGFc transfected HEK293 (2) cell lysate.

Figure 3:Western blot analysis using LRP6 mAb against HEK293 (1) and LRP6 (AA: extra 1198-1370)-hIgGFc transfected HEK293 (2) cell lysate.

Flow cytometric

Figure 4:Flow cytometric analysis of HL-60 cells using LRP6 mouse mAb (green) and negative control (red).

Figure 4:Flow cytometric analysis of HL-60 cells using LRP6 mouse mAb (green) and negative control (red).

For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 31564

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