Mouse Monoclonal Antibody to ITGB7
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/a03f0969b88dae3b18d6f4d0ec36bb5ed5fafdcc15ffac245fcc9462e3dc7378.jpg?v=1666706125)
![Figure 2:Western blot analysis using ITGB7 mAb against human ITGB7 (AA: 20-174) recombinant protein. (Expected MW is 43.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/98e22cb2b56d2be7fc7d91a7f8f7dd06f9da71674a776cb8ff634cf5a2df6385.jpg?v=1666706125)
![Figure 3:Western blot analysis using ITGB7 mAb against HEK293-6e (1) and ITGB7 (AA: 20-174)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31eda7dffc597214c10e6b3220c08c34bc368e3d46fda1af19459505ab33e78f.jpg?v=1666706125)
![Figure 4:Immunofluorescence analysis of Hela cells using ITGB7 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/6e1dc986dde60b2819fe7745628758918f016a71b548d4e43bd7d173bee55555.jpg?v=1666706125)
![Figure 5:Flow cytometric analysis of HL-60 cells using ITGB7 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/c63fca287dbc9962cbd2947632cc9ad76792bb9806f48c299d9a884810aa26a9.jpg?v=1666706125)
![Figure 6:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGB7 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/ad0df5a1790a3df25a8ca6e0b7d69e74290721c9700d0cbc77fc6725048cd140.jpg?v=1666706125)
![Figure 7:Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using ITGB7 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/2091b924f7491ec450d017eb377b0d70c8858f0e5959cfe7a350159c362b85da.jpg?v=1666706125)