ITGA2B Primary Antibody
Item Information
Catalog #
Size
Price
Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Product Overview
Entrez GenelD
3674
Aliases
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2
Clone#
2E10C9
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1. Pediatr Blood Cancer. 2012 Aug;59(2):335-8.
2. Blood. 2011 Dec 1;118(23):5996-6005.
2. Blood. 2011 Dec 1;118(23):5996-6005.
Product Image
Western Blot
Figure 1: Western blot analysis using ITGA2B mAb against human ITGA2B recombinant protein. (Expected MW is 36.9 kDa)
Western Blot
Figure 2: Western blot analysis using ITGA2B mAb against HEK293 (1) and ITGA2B (AA: 45-149)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4: Flow cytometric analysis of HL60 cells using ITGA2B mouse mAb (green) and negative control (purple).
Immunohistochemical analysis
Figure 5: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGA2B mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 6: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ITGA2B mouse mAb with DAB staining.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.