EP300 Primary Antibody
Item Information
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Price
Description
EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Product Overview
Entrez GenelD
2033
Aliases
p300; KAT3B
Clone#
7D8A6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of EP300 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Biol Chem. 2007 Mar 30;282(13):9678-87.
2. Mol Cell Biol. 2008 Feb;28(4):1383-92.
2. Mol Cell Biol. 2008 Feb;28(4):1383-92.
Product Image
Western Blot
Figure 1: Western blot analysis using EP300 mouse mAb against truncated EP300-His recombinant protein (1).
For Research Use Only. Not for use in diagnostic procedures.