CD81
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene.
2.Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183419.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347ea.jpg?v=1669029608)
![Figure 2:Western blot analysis using CD81 mAb against human CD81 (AA: 113-201) recombinant protein. (Expected MW is 35.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347rwb.jpg?v=1669029608)
![Figure 3:Western blot analysis using CD81 mAb against HEK293-6e (1) and CD81 (AA: 113-201)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347twb.jpg?v=1669029608)
![Figure 4:Western blot analysis using CD81 mouse mAb against Ramos (1), Raji (2), HEK293 (3), HepG2 (4), Hela (5), K562 (6), Jurkat (7), PC-12 (8) and C6 (9) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347lwb.jpg?v=1669029608)
![Figure 5:Flow cytometric analysis of THP-1 cells using CD81 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347fcm.jpg?v=1669029608)
![Figure 6:Immunohistochemical analysis of paraffin-embedded tonsil tissues using CD81 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32347ihc.jpg?v=1669029608)