CASP9 Primary Antibody
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31748ea_16.jpg?v=1666704449)
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31746ea_17.jpg?v=1666704449)
![Figure 2:Western blot analysis using CASP9 mAb against human CASP9 (AA: 331-416) recombinant protein. (Expected MW is 36 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31748rwb_18.jpg?v=1666704449)
![Figure 3:Western blot analysis using CASP9 mAb against HEK293 (1) and CASP9 (AA: 331-416)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31748twb_19.jpg?v=1666704449)
![Figure 4:Flow cytometric analysis of Hela cells using CASP9 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31748fcm_20.jpg?v=1666704449)