HER2 CAR-T cells (HER2 scFv-TM-CD28-CD3z /// GFP)

HER2 (hormone epidermal growth factor receptor 2) is a type I membrane receptor kinase encoded by the ERBB2 gene and overexpressed in a variety of cancers including breast, gastric, lung and ovarian cancers. HER2 expression is associated with the development and progression of certain aggressive types of breast cancer.

ProMab's PM-CAR1083 primary human CAR-T cells express an anti-HER2 CAR containing a HER2-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. In addition, PM-CAR1083 CAR-T cells express eGFP, driven by a separate promoter. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.