CLL-1 CAR-T cells (CLL-1 scFv-TM-41BB-CD3z)

CLL-1 (C-type lectin-like molecule-1), encoded by the CLEC12A gene, is a type II membrane protein expressed on myeloid cells including monocytes, dendritic cells, neutrophils and eosinophils. Also known as C-type lectin domain family 12 member A, CLL-1 is upregulated in acute myeloid leukemia (AML) patients.

ProMab's PM-CAR1092 primary human CAR-T cells express an anti-CLL-1 CAR containing a CLL-1-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.