VEGFR2 hinge-TM-CD28-CD3z

VEGFR2 (vascular endothelial growth factor receptor 2) is a type I protein encoded by the KDR gene and expressed on endothelial cells. VEGFs and their receptors are important for angiogenesis and are thus an important therapeutic target for highly vascularized tumors. ProMab's PM-CAR1104 primary human CAR-T cells express an anti-VEGFR2 CAR containing ProMab's VEGFR2-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain.