UPK1A hinge-TM-4-1BB-CD4z

UPK1A (uroplakin-1a) is a tetraspanin membrane protein expressed primarily by terminally differentiated urothelial cells in the urinary bladder. UPK1A has been shown to be a diagnostic marker for urothelial carcinoma and may also play a role in muscle-invasive carcinomas. ProMab's PM-CAR1108 primary human CAR-T cells express an anti-UPK1A CAR containing a UPK1A-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain.