Humanized ROR1 CAR-T cells (ROR1 scFv-TM-41BB-CD3z)

ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a type 1 membrane protein that modulates neurite growth in the central nervous system. ROR1 is expressed in a subset of cancers and may facilitate metastasis.

ProMab's PM-CAR1044 primary human CAR-T cells express an anti-ROR1 CAR containing a humanized ROR1-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.