CD7 scFv-hinge-TM-4-1BB-CD4z

CD7 is a type 1 membrane protein expressed on lymphocytes including T cells and NK cells. CD7 binding to its ligand K12/SECTM1 acts as a costimulatory molecule via type II phosphatidylinositol-4 kinase, inducing cytokine secretion - IL-2 for T cells, IFN-gamma for NK cells. Anti-CD7 CAR-T cells can be used for T cell malignancies or to block T cell infiltration into solid tumors. ProMab's PM-CAR1106 primary human CAR-T cells express an anti-CD7 CAR containing a CD7-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain.