CD24scFv-TM28-CD28-CD3z
Item Information
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Description
ProMab's PM-CAR1059 primary human CAR-T cells express an anti-CD24 CAR containing a CD24-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain.
Product Overview
Cell Type Tested
T cells
Formulation
CS10 CryoStor Medium (Sigma Aldrich, Cat, #C2874)
Cell Viability
>90%
Mycoplasma Testing
The cells has been screened using a PCR-based mycoplasma detection kit to conirm the absence of mycoplasma species.
Storage
-80°C; liquid nitrogen
Shipping & Handing
This product will be shipped in a box containing dry ice at a temperature of -70°C.
Product Image
CAR Structure
Figure 1. Schematic representation of the scFv, costimulatory domain, and activation domain of PM-CAR1059. This construct targets CD24.
RTCA
Figure 2. CD24-CAR-T cells specifically kill A375-CD24-positive cancer cells. Top panel: A375 (24-positive) cells; lower panel: A375 (CD24-negative cells).
RTCA
Figure 3. CD24-CAR-T cells kill A1847 ovarian cancer cells.
For Research Use Only. Not for use in diagnostic procedures.